Solian Tablets

Solian Tablets (Amisulpride) - Product Information

Solian tablets (Amisulpride) are indicated for the treatment of acute and chronic schizophrenic disorders, in which positive symptoms (such as delusions, hallucinations, thought disorders) and/or negative symptoms (such as blunted affect, emotional and social withdrawal) are prominent, including patients characterised by predominant negative symptoms.

Solian tablets is an atypical antipsychotic agent which corrects the imbalance of chemical substances acting on the nervous system.

Solian tablets are manufactured by Sanofi India Limited in the strengths of 50 mg, 100 mg, 200 mg and 400 mg . We also have in stock Generic Zyprexa (Oliza Tablets) and Generic Seroquel (Qutipin Tablets) which are also used to treat the same indications.

Name of the Drug

We supply original Solian Tablets manufactured by Sanofi India Limited.

Manufacturer of Solian Tablets

Sanofi India Limited  
Website: www.sanofiindialtd.com

Active Ingredient present in Solian Tablets

The active pharmaceutical ingredient in Solian tablets is Amisulpride. Each Solian tablet contains 50 mg, 100 mg, 200 mg or 400 mg of Amisulpride depending on the strength of the tablet.

Uses of Solian Tablets

Solian belongs to a group of medications called 'anti-psychotics'. This medicine is used to treat an illness called schizophrenia. Schizophrenia can make an affected person feel, see or hear things which do not exist, have strange and frightening thoughts, change how you act, and make them feel alone.

Solian works by improving disturbed thoughts, feelings and behaviour. This medicine is used to treat schizophrenia when it starts and also over the long term.

Solian Tablets Dosage

Swallow Solian tablets whole with plenty of water before a meal. Do not drink alcohol while you are taking Solian as this can affect the way the medicine works.
The dosage of Solian tablets for various indications is given below:
Treatment of Schizophrenia:
Predominantly negative episodes:
Doses between 50 mg/day and 300 mg/day are recommended. Doses should be adjusted as per the needs of the individual patient. The optimum dosage is about 100 mg/day.
For patients with mixed positive and negative symptoms, doses should be adjusted to obtain optimal control of positive symptoms.

Acute psychotic episodes:
When initiating treatment oral doses between 400 mg/day and 800 mg/day are recommended. The maximum dose should never exceed 1200 mg.
Thereafter the dosage should then be maintained or adjusted according to the patient's individual response. In all cases, the maintenance treatment should be established as per the response of the individual patient with the minimum effective dose.

Storage

Store Solian tablets at controlled room temperature at a temperature below 30°C. Protect from light.

Warnings And Precautions For Use

In the event of Neuroleptic Malignant Syndrome, a potentially fatal complication which is characterized by hyperthermia, muscle rigidity, autonomic instability, altered consciousness and elevated CPK that occurs particularly with high daily doses, all antipsychotic drugs including Solian must be discontinued.

Hyperglycaemia (an excess of glucose in the bloodstream) has been observed in patients treated with some atypical antipsychotic agents, including Amisulpride tablets, therefore patients with an established diagnosis of diabetes mellitus or with risk factors for diabetes who are started on Solian, must be subject to appropriate glycaemic monitoring.

Solian is eliminated by the renal route. In patients with renal insufficiency, the dose has to be decreased or intermittent treatment could be considered.

Solian can lower the seizure threshold in some patients. Therefore patients with a history of epilepsy must be closely monitored during therapy with Amisulpride tablets .

In elderly patients, Solian, like other neuroleptics, must be used with particular caution because of a possible risk of hypotension or sedation. Further reduction in dosage may also be necessary because of renal insufficiency.

As with other antidopaminergic agents, caution should be also exercised when prescribing Solian to patients with Parkinson's disease since it can cause worsening of the disease. Solian should be used only if neuroleptic treatment cannot be avoided.

Acute withdrawal symptoms including nausea, vomiting and insomnia can occur after abrupt cessation of high doses of antipsychotic drugs. Recurrence of psychotic symptoms can also occur in some patients, and the emergence of involuntary movement disorders (such as akathisia, dystonia and dyskinesia) has also been reported. Therefore, gradual withdrawal of Amisulpride tablets (Solian) is highly advisable.

Solian Overdosage

Experience with Amisulpride tablets (Solian) in overdosage cases is limited. Exaggeration of the known pharmacological and adverse effects of Amisulpride have been reported in the observed cases. The observed symptoms of Solian overdose may include drowsiness, sedation, hypotension, extrapyramidal symptoms and coma.

Fatal outcomes have been reported mainly in combination with other psychotropic agents. During treatment in cases of acute overdose, the possibility of multiple drug intake must be considered.

There is no specific antidote to amisulpride. Appropriate supportive measure should therefore Close supervision of vital functions must be instituted and, because of the risk of prolongation of QT interval, continuous cardiac monitoring until the patient recovers has to be carried out.

Solian Contraindications

Solian tablets are contraindicated in patients with a hypersensitivity to Amisulpride or any inactive ingredient present in Solian tablets. Solian are also contraindicated in the following cases:

• Serious hypertensive episodes have been reported in patients with pheochromocytoma using antidopaminergic drugs, including some benzamides. It is therefore advisable to abstain from prescribing Solian tablets in known or suspected pheochromocytoma carriers.
• Children under 15 years of age, because no clinical data are available on this age group
• Breast-feeding Women
• Women of childbearing potential unless using adequate contraception.
• Known or suspected prolactin-dependent tumors, e.g. prolactin-secreting pituitary adenoma and breast cancer.
• Solian is also contraindicated in combination with: citalopram, escitalopram, non-antiparkinsonian dopamine agonists (cabergoline, quinagolide), levodopa

Solian Side Effects

In case you have any of the following Solian side effects please inform your doctor as soon as possible :

Very Common (affects more than 1 in 10 people)
- Trembling, muscle stiffness or spasm, slow movement, producing more saliva than usual or feeling restless. Common (affects less than 1 in 10 people)
- Movements that you cannot control, mainly of the arms and legs (These symptoms can be reduced if your doctor lowers your dose of Solian tablets or prescribes an additional medicine)

Uncommon (affects less than 1 in 100 people)

- Movements that you cannot control, mainly of the face or tongue Other side effects include:

Common (affects less than 1 in 10 people)
- Difficulty sleeping (insomnia) or feeling anxious or agitated
- Feeling drowsy or sleepy
- Constipation, feeling or being sick, dry mouth
- Putting on weight

Stop taking Solian and see a doctor or go to a hospital immediately if:

- You have a high temperature, sweating, stiff muscles, fast heartbeat, fast breathing and feel confused, drowsy or agitated. These could be the symptoms of a serious but rare side effect called ‘neuroleptic malignant syndrome’
- You have an unusual heart rate, very fast heart rate or chest pain which could result in a heart attack or life-threatening heart disorder
- You have blood clots in the veins especially in the legs (symptoms can include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing. If you notice any of these symptoms seek medical advice immediately.
- You get more infections than usual. This could be because of a blood disorder (agranulocytosis) or a decrease in the number of white blood cells (neutropenia).

Amisulpride During Pregnancy

Amisulpride has been classified by the US FDA as category B3. Do not use this medicine without your doctor's consent in case you are pregnant. Stop using this medication and inform your doctor immediately if you become pregnant during treatment.

Neonates exposed to antipsychotics (including Solian tablets) during the third trimester of pregnancy are at risk of adverse reactions including extrapyramidal and/or withdrawal symptoms that can vary in severity and duration following delivery.

Nursing Considerations

It is not known whether Amisulpride is excreted in breast milk, breast-feeding is therefore contra-indicated.
Do not use Amisulpride tablets without telling your doctor if you are breast-feeding a baby.

Buy Solian Pills Online at Only $0.70 per Pill

You can buy Amisulpride tablets online from Clear Sky Pharmacy at a cheap price. 100 mg, 200 mg and 400 mg pills, manufactured by Sanofi India Limited, are supplied in a blister strip of 10 tablets and Solian 50 mg is supplied in a blister strip of 15 tablets. The 50 mg tablets cost only $0.70 per unit when you place an order for 210 tablets.

Disclaimer

The above information is provided to the best of our knowledge and in good faith, it is without a warrant of any kind, expressed or implied.

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