Nolvadex Tablets (Tamoxifen Citrate) - Product Information
Nolvadex tablets are nonsteroidal anti-estrogen tablets containing Tamoxifen Citrate, which basically functions as an anti-cancer drug. Tamoxifen Citrate blocks the biological effects of the female estrogen hormone on the development of breast cancer. Tamoxifen Citrate tablets (Nolvadex) are prescribed as oral therapy in women as well as men who have developed breast tumors which are dependent on estrogen for their growth and survival in the body. Nolvadex tablets are also recommended as treatment in women who have a higher risk of developing breast cancer to effectively lower the possibility of contracting breast cancer. Nolvadex tablets are suggested as anti-cancer treatment after the completion of surgery, radiation, and chemotherapy to prevent the metastasis of the cancer cells to the other parts of the body and also to lower the chances of the recurrence of tumors. Since Nolvadex tablets mimic the characteristic of an anti-estrogen, body-builders and weight-training athletes also use Nolvadex tablets to elude the adverse effects of estrogen such as gynecomastia, water retention that develop at the end of a steroid cycle. In our online pharmacy, Nolvadex tablets are available in the strength of 10 mg of Tamoxifen Citrate.
Nolvadex tablets. Other brand names for Tamoxifen Citrate tablets include Istubal, Valodex, Tamoxifen Apo-Tamox, Gen-Tamoxifen, Novo-Tamoxifen, Tamofen, Tamone, Citofen, Crisafeno, Diemon, Istubol, Kessar, Noltam, Nourytam, Novo-Tamoxifen, Oncomox, PMS-Tamoxifen, Tamoxifene, Tamoxifen, Retaxim, Tamizam, Tamoxasta, Tamoxen, Valodex, Zemide, Tamoxifeno, and Soltamox.
Manufacturer of Nolvadex Tablets
Nolvadex tablets, available in our online pharmacy are manufactured by Astra Zeneca UK Ltd . Nolvadex tablets are also known as Tamoxifen Citrate tablets. (Website: www.astrazeneca.com)
Active Pharmaceutical Ingredient
The active pharmaceutical ingredient in Nolvadex tablets is Tamoxifen Citrate. Each Nolvadex tablet contains either 15.2 mg or 30.4 mg of Tamoxifen Citrate which is equivalent to 10 mg or 20 mg of Tamoxifen respectively. The inactive ingredients present in Nolvadex pills are carboxymethylcellulose calcium, magnesium stearate, mannitol and starch.
What are Nolvadex Tablets Used For?
Nolvadex tablets, manufactured by Astra Zeneca UK Ltd, contain Tamoxifen Citrate which blocks the biological effect of the female hormone called estrogen on breast cancer. Nolvadex tablets are typically administered as oral therapy for cancer treatment in men and women who have been diagnosed with breast cancer whose growth and survival is dependent on the estrogen hormone. Nolvadex tablets prevents the growth of breast cancer by disturbing the effects of estrogen hormone on the breast tissue.
Tamoxifen Citrate can be used for cancer treatment after the patient has undergone primary treatment such as surgery, radiation, and chemotherapy. Nolvadex tablets are used as preventive therapy to reduce the risk of breast cancer in women who have been diagnosed to have a higher risk of developing estrogen dependent breast tumors. Tamoxifen Citrate tablets (Nolvadex) have been used as breast cancer therapy in women for a very long time. Treatment with Nolvadex tablets is usually recommended in women of child-bearing age as well as post-menopausal women.
Nolvadex tablets also helps to prevent the recurrence of breast cancer. The administration of Nolvadex tablets also reduces the risk of developing breast cancer in the other breast in women who have already had breast cancer in the past. In addition, Tamoxifen Citrate tablets is used in women to effectively decrease the risk of development and metastasis of breast cancer who have a medical condition called ductal carcinoma in situ (DCIS) (breast cancer located in the milk ducts and which has not spread to other body parts) and have already received breast cancer surgery and radiation therapy.
In certain cases, Tamoxifen Citrate tablets are also used to ease the symptom of breast pain (mastalgia) because it decreases the blood level of estrogen hormone which causes the breast swelling. Nolvadex tablets are also used to treat males who are diagnosed with breast cancer. Women with anovulatory disorders such as irregular menstrual cycles and absence of ovulation cycles are also suggested a therapy with Tamoxifen Citrate (Nolvadex tablets). Tamoxifen Citrate tablets are also used for the treatment of mania in patients suffering from bipolar disorders.
Treatment with Nolvadex tablets (Tamoxifen Citrate tablets) is beneficial as an anabolic steroid cycle auxiliary drug and as a recovery or as a post anabolic steroid cycle therapy drug. Body builders use Nolvadex tablets towards the end of a steroid cycle as anti-aromatase therapy to reduce the amount of circulating estrogen, decrease water retention, and to prevent estrogen related gynecomastia (growth of breast tissues in men). Nolvadex tablets act as anti-estrogen, which aids in bringing the testosterone level back to normal because the estrogen levels are elevated towards the end of a steroid cycle.
Nolvadex Dosage - How to Take Tamoxifen Citrate Tablets?
You should use Nolvadex tablets (Tamoxifen Citrate) exactly as recommended by your doctor. Your doctor may suggest a dosage of Nolvadex tablets depending whether Nolvadex tablets are used for the treatment or prevention of breast cancer, the stage of cancer, body weight, other medical conditions, and current medications. Tamoxifen Citrate should be taken once or twice a day with a glass of water, after a meal to avoid indigestion problems. Try to maintain a regular schedule for the medication such that you take Nolvadex tablets at the same time every day, to get the maximum benefit of the medication. Doctors usually recommend a dosage of a single Nolvadex tablet (Tamoxifen Citrate) once daily after a meal.
If the daily dosages for the treatment of your medical condition exceeds 20 milligrams, you will be ideally advised to spilt into two doses, one half in the morning and the other in the evening, or as recommended by your doctor. Your doctor may alter the dosage of Nolvadex tablets and dosage period depending on your response to treatment. Treatment with Nolvadex tablets should be continued for a period of five years, unless your doctor gives you different instructions. You may need to monitor your health through frequent blood tests and mammography during the course of treatment with Nolvadex tablets.
The recommended daily dosage of Nolvadex tablets for the treatment of metastatic breast cancer in men and women is 20 to 40 mg, preferably in multiple doses, one in the morning and the other in the evening. Women diagnosed with Ductal Carcinoma in Situ, will ideally be advised a daily dosage of 20 mg of Nolvadex tablets for a period of 5 years after they have undergone surgery and radiation therapy. If you're taking Tamoxifen Citrate as a preventive therapy to reduce the occurrence of breast cancer, you will be advised a daily dosage of 20 mg Nolvadex tablets for a period of 5 years. The recommended daily dosage of Nolvadex tablets for the treatment of infertility is 10 to 40 mg during days 3-7 of the menstrual cycle. Patients suffering from bipolar disorders are usually prescribed a daily dosage of 20 to 40 mg of Nolvadex tablets which should be orally administered twice a day.
Bodybuilders who use Nolvadex tablets after 3-4 weeks post the end of a steroid cycle are usually advised a daily dosage of 10 mg - 60 mg of Tamoxifen Citrate.
Nolvadex Mechanism of Action - How Does Tamoxifen Citrate Work?
Nolvadex is a non-steroidal substance which acts as anti-estrogen a SERM (Selective Estrogen Receptor Modulator) by competing with estrogen for its specific binding sites in cancer cells. Tamoxifen Citrate treatment is effective only in those tumors which are positive for the presence of estrogen receptors (ER+), which signifies the requirement of estrogen for the growth of the tumor. Tamoxifen successfully inhibits the effect of estrogen on these cancer cells thus preventing their growth and survival. Tamoxifen Citrate is commonly used as hormone therapy for breast cancer because it prevents the development of breast tumors and also reduces the growth of existing tumors.
Bodybuilders use Nolvadex tablets to reduce the detrimental effects of elevated estrogen levels that are present as by-products toward the end of a steroid cycle. Treatment with Nolvadex tablets blocks the production of estrogen. Bodybuilders' can decrease the possibility of side effects of steroid cycle such as water retention, gynecomastia.
Nolvadex Tablets - Missed Dose
If you miss your regular dose of Nolvadex tablets, take it as soon as you remember. You can continue your regular schedule the next day. If you remember the missed Nolvadex tablets the next day, take your regular dose and skip the missed dose. Do not take a double dose to compensate the missed dose of Nolvadex tablets.
Storage Instructions for Nolvadex Tablets
Store the pack of Nolvadex tablets at room temperature (20 - 25°C), protected from heat, moisture, and sunlight. Retain the original packing of the medication and do not consume Tamoxifen Citrate tablets (Nolvadex) beyond its expiration date printed on the blister pack. Keep the pack of Nolvadex tablets away from the reach of children and pets. Do not discard Nolvadex tablets along with domestic waste or sewage. Consult your doctor or pharmacist about the correct method of disposal.
Warnings and Precautions to be taken when using Nolvadex Tablets
Before beginning the treatment with Nolvadex tablets , discuss your personal and family medical history with your doctor. Inform your doctor if you have blood clots (e.g., deep vein thrombosis, pulmonary embolism, stroke) or conditions that require treatment with an anti-coagulant (such as warfarin), high cholesterol/triglycerides, limited or no ability to walk (immobility), diabetes, high blood pressure, smoking, cataracts, liver disease, or are receiving chemotherapy or radiation.
Please inform your doctor if you have an allergy or have had an allergic reaction in the past to Tamoxifen Citrate or any inactive ingredient in Nolvadex tablets.
Tamoxifen Citrate Interactions:
Before beginning the oral therapy of Nolvadex tablets, please inform your doctor of all your current medications including prescription drugs, over the counter medications, mineral supplements, herbal products, and vitamins. Nolvadex is known to have drug interactions with aminoglutethimide, anastrozole, letrozole (Femara), bromocriptine (Parlodel), blood thinners" (e.g., warfarin), estrogens, hormonal forms of birth control (e.g., birth control pills, patches, implants), phenobarbital, rifamycins (e.g., rifampin), St John's wort, cimetidine (Tagamet), SSRI antidepressants (fluoxetine/paroxetine/ sertraline/ tranylcypromine), medroxyprogesterone, clozapine (Clozaril, FazaClo), cyclophosphamide (Cytoxan, Neosar), isoniazid, methimazole Tapazole), nicardipine (Cardene), pioglitazone (Actos), ropinirole (Requip), ticlopidine (Ticlid), tranylcypromine (Parnate), anti-malaria medication such as chloroquine (Arelan) or pyrimethamine (Daraprim), or quinine (Qualaquin), an antibiotic such as terbinafine (Lamisil), miodarone (Cordarone, Pacerone), quinidine (Quin-G), delavirdine (Rescriptor) or ritonavir (Norvir), aripiprazole (Abilify), chlorpromazine (Thorazine), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), perphenazine (Trilafon), or thioridazine (Mellaril).
Nolvadex Tablets Contraindications:
The treatment with Nolvadex tablets is contraindicated in patients who are allergic to Tamoxifen Citrate or any inactive ingredients present in Nolvadex tablets. Nolvadex tablets are also contraindicated in pregnant women and breastfeeding mothers. Women who are on a treatment with an anticoagulant or women with a medical history of deep vein thrombosis or pulmonary embolus should not be administered Nolvadex tablets.
Tamoxifen Citrate Tablets - Driving and Other Activities:
Tamoxifen Citrate tablets may make you light-headed or impair your vision. Avoid activities such as driving, using machinery, or performing any activity that requires complete vigilance or perfect vision until you are sure about your safety.
Nolvadex Tablets - Pregnancy and Breastfeeding:
Nolvadex tablets is a category D medication i.e. the administration of Nolvadex tablets in pregnant women has known to cause defects in a developing fetus. Pregnant women should not be administered Nolvadex tablets. Women should use two non-hormonal method of contraception such as condoms and diaphragm with spermicide during the treatment with Tamoxifen Citrate tablets and until two months after the discontinuation of treatment. The risk of transmission of Tamoxifen Citrate through breast milk is unknown. Women on a course of Tamoxifen tablets are ideally advised to avoid breast-feeding because of the potential risk to the infant. Women planning to get pregnant and lactating mothers wanting to nurse an infant during the course of Nolvadex tablets should seek their doctor's expert opinion.
Surgery and Regular Medical Tests:
If you plan to have surgery or any dental procedure, inform your doctor, anesthetist, or dentists about your course of Nolvadex tablets. In case of an emergency medical treatment, please inform the practitioner about your course of Nolvadex tablets and the details of your last dose.
Side Effects of Nolvadex Tablets
The following side effects have been reported during the course of treatment with Nolvadex tablets:
Cardiovascular System: - chest pain, rapid breathing, fast heart rate, stroke.
Central Nervous System: - headache, mental/mood changes, confusion.
Eye and ENT: - vision changes (e.g., blurred vision), eye pain, and cataract.
Gastrointestinal System: - nausea, stomach/abdominal pain, persistent vomiting, constipation, pulmonary embolism.
Genitourinary System: - dark urine, unusual vaginal bleeding or discharge, irregular menstrual periods, pain or pressure in your pelvic area, new breast lump, vaginal itching or dryness, irregular periods, decrease in the amount of urine, ovarian cyst.
Musculoskeletal System: - leg cramps, muscle aches, numb/tingling skin, swelling of ankles/feet.
Hypersensitivity: - rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
General: - hot flashes, hair thinning, easy bruising/bleeding, unusual tiredness, yellowing eyes/skin, signs of infection (e.g., fever, persistent sore throat), sudden cough, wheezing, loss of appetite, increased thirst, weight gain, weight loss.
Inform your doctor immediately if you experience any of these side effects. This is not a comprehensive list of all the possible side effects of Nolvadex tablets. If you develop any other medical conditions during the course of treatment with Tamoxifen Citrate tablets, please consult your doctor immediately.
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